Main information about Bactrim
Bactrim contains two active ingredients which have antibacterial characteristics. This drug has Trimethoprim and sulfamethoxazole.
The active ingredients of Bactrim break sequential processes in the bactericidal cell:
- Sulfamethoxazole breaks synthesis of dihydrofolic acid inside the cells of the pathogenic microflora
- Trimethoprim breaks the next chain and prevents a recovery of dihydrofolic acid
As a result of this process, morbific microorganisms do not receive ingredients needed for the development, and therefore they lose their functions and gradually die.
Bactrim antibiotic provides a bactericidal action to bacteria with gram-positive and gram-negative structure of the cellular wall.
The maximal concentration of Bactrim in the blood plasma is observed in 2-3 hours after a one-time use of the therapeutic dose. This is a fast value due to which a therapeutic effect happens faster than using other antibacterial drugs.
The highest concentrations of Bactrim are observed in the organs of the respiratory and urinary systems, and therefore this drug is more effective in the treatment of cystitis, urethritis, gonococcal urethritis, prostatitis, pyelonephritis, chronic bronchitis, pneumonia and other bacterial diseases of these systems.
In addition, Bactrim shows a high efficiency in the treatment of infections of the gastro-intestinal tract, surgical infections, gonorrhea, and infections of HENT.
Administration and dose of Bactrim
A standard therapy of the infectious diseases suggests the use of Bactrim pills 480 mg 2 times per day with the interval of 8-12 hours. If infection is severe, the pills of Bactrim 480 mg are used 3 times per day.
The maximal daily dose of Bactrim is 4 pills in the dose of 480 mg.
The length of the treatment usually takes 12-14 days in case of the acute infectious process. There is no clear length of the treatment for chronic infections.
Doses of Bactrim depend on certain medical image both in adults and children.
Children are prescribed the dose of Bactrim according to their age:
- Children at the age of 6 to 12 are prescribed a pill of Bactrim 480 mg 1-2 times per day
- Children at the age of 2 to 6 are prescribed Bactrim 240 mg 1-2 times per day
- Children under 2 years old are prescribed syrup, 1 measuring spoon 1-2 times per day
Recommendations for the use
- There are many contraindications during which patients are not prescribed Bactrim: kidney or liver failure, anemia, leukopenia, pregnancy, lactation, agranulocytosis
- Bactrim pills should be used during meals, or right after meals and with a full glass of water
- Bactrim is not prescribed children under 6 months
- Do not take Bactrim with bacteriostatic antibiotics
- To prevent candidiasis, take a pill of Fluconazole every 3rd day during the treatment
The most common side effects of Bactrim are:
- Nausea and vomiting
- allergic skin reactions
- Reduced kidney function
If the side effects appeared, do not change the scheme of the treatment until they do not cause a severe discomfort.