Tramadol

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Description

Main information about Tramadol

Tramadol is an opioid analgesic which provides a central action and inhibits painful syndrome of any severity. This drug is quickly absorbed from the gastro-intestinal tract during the peroral use. In 2 hours, the maximal amount of the active ingredients is concentrated in the blood. It is easily spread in all organs and tissues, and provides an evident analgesic effect.

Tramadol is inferior to morphine and codeine but it has a poor connection to the opioid receptors. A medical addiction develops slowly during the use of Tramadol in comparison with other opioid analgesics; and euphoria appears only during the use of very high doses.

The analgesic action of Tramadol begins in 15-20 minutes after the peroral use. It binds to the receptors of the central nervous system and spinal cord and blocks a movement of the painful impulses to the brain.

The analgesic effect is increased during the connection with opioid receptors, and a painful threshold is increased a lot.

Tramadol is used in order to anesthetize during the various pathologies:degenerative diseases of the musculoskeletal system, trauma, neurology, cardiovascular diseases with marked pain syndrome (including myocardial infarction), pain during malignant tumors and others.

Administration and dose of Tramadol

To reduce severe pain, Tramadol is used in the dose of 50 mg every 4-6 hours.

The pills may be used regardless of meals because food does not influence on the bioavailability of the active ingredients. The pills should be used with enough water (do not take it with juice or milk).

Teenagers over 16 years old and adults are allowed taking up to 400 mg of Tramadol per day (2 pills of Tramadol 50 mg every 6 hours).

Children at the age of 5 to 14 years old are recommended to take 1-2 mg per 1 kg of the body weight. The daily dose should be divided into 3-4 parts.

To reduce painful syndrome, it is recommended to use a low maintaining dose of Tramadol to prevent a relapse. The period of the treatment should be maximally short in order to reduce a risk of the formation of a medical/opioid addiction.

Recommendations for the use

  • It is strictly contraindicated to take more than 400 mg of Tramadol per day. Due to the overdose, euphoria, disorders of the central nervous system and mind may happen
  • Children under 14 years old should use either rectal suppositories of Tramadol, or other parenteral methods to avoid a gastro-intestinal tract
  • Tramadol provides a strong sedative effect, and therefore do not take it with MAO inhibitors, antidepressants, sleeping pills, alcohol, opioids. Any products/medicines interacting with the central nervous system may increase the action of Tramadol and cause side effects
  • Tramadol is not prescribed pregnant women, acute intoxications of the body, and severe dysfunctions of liver

 

Side effect

The side effects of Tramadol may be controlled. The side effects appear usually seldom during the use of the correct dose. These are low blood pressure, constriction or dilation of the pupils, nausea, muscle cramps, dizziness, and drowsiness.

But in case of the overdose, a severe respiratory distress, coma, vomiting, cardiovascular collapse may happen. If these side effects appeared, seek for a medical aid as soon as possible.