Main information about Zofran.

Zofran is a medication of the new generation to inhibit nausea and vomiting. The drug contains Ondansetron.

The use of Zofran prevents the appearance of vomiting reflex. It is unknown why this drug works this way and inhibits a vomiting reflex.

It is just known that Zofran inhibits central cores of the vomiting reflex by means of blocking serotonin 5HT receptors.

It also reduces the activity of nervus vagus in the central nervous system and blocks some section of the brain which are responsible for the vomiting reflex.

Zofran does not provide a sedative and intense inhibiting action to the central nervous system. Using the drug does not reduce a psychomotor activity, and therefore a patient does not feel changes happening during the use of the drug.

Zofran provides a high efficiency during suppress the vomiting reflex caused by motion sickness, chemotherapy, radiotherapy after surgery or diagnostic procedures.

Administration and dose of Zofran

A dose of Zofran depends on the individual peculiarities of a patient and causes of vomiting. The daily dose varies from 8 to 32 mg per day.

In case of chemotherapy, Zofran is prescribed in the dose of 8 mg directly before chemotherapy. Then, 2 more pills of Zofran 8 mg are prescribed within 24 hours.

The use of Zofran is oral in the dose of 4 mg 2 times per day, and this may be continued within 5 days after chemotherapy.

In case of sea sickness, Zofran 8 mg should be used 1-2 times per day with the interval of 10-12 hours.

Children and teenagers at the age of 2 to 17 years old are prescribed an individual dose of Zofran.

Recommendations for the use

  • Senior patients should not lower the daily dose of Zofran
  • Zofran may slow the motility of the large intestine, so that it is prescribed patients with bowel obstruction only under doctor’s control
  • Stop breast-feeding during the treatment because it is unknown whether this medicine penetrates into the breast milk or not. The use of Zofran is contraindicated during pregnancy
  • Patients with diseases of the cardiovascular system (arrhythmia, myocardial infarction) who take the cardiac drugs should careful take Zofran. If there is discomfort in the heart area, the use of the pills should be stopped
  • The daily dose of the drug should not exceed 8 mg for patients with dysfunctions of liver
  • Children under 2 years old are not prescribed this medicine to treat nausea and vomiting
  • Patients with kidney diseases should not adjust the daily dose

Side effect.

The use of Zofran may be accompanied by the following side effects: nausea, hiccups, dry mouth, constipation, decreased blood pressure, cramps, dizziness, and urticaria.

The appearance of allergy tells about the intolerance of Zofran, and therefore the treatment should be stopped. If the side effects bring light discomfort, the daily dose may be reduced and the treatment may be continued.